Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.

Abstract

1. Lewis rats (n = 7 or 8) were dosed with methoxyphenamine with and without prior administration of various doses of either quinine or its diastereomer quinidine. Methoxyphenamine and its N-desmethyl, O-desmethyl and aromatic 5-hydroxy metabolites were quantified in 0-24 h urine. 2. The oxidative routes of methoxyphenamine metabolism which had been… (More)

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@article{Muralidharan1991QuinineIA, title={Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.}, author={Guruprasath Muralidharan and Edward M. Hawes and Gordon. McKay and Kamal K. Midha}, journal={Xenobiotica; the fate of foreign compounds in biological systems}, year={1991}, volume={21 11}, pages={1441-50} }