Quinine-induced alterations of electrically evoked otoacoustic emissions and cochlear potentials in guinea pigs.

@article{Zheng2001QuinineinducedAO,
  title={Quinine-induced alterations of electrically evoked otoacoustic emissions and cochlear potentials in guinea pigs.},
  author={Jiefu Zheng and Tianying Ren and Anand A. Parthasarathi and Alfred L. Nuttall},
  journal={Hearing research},
  year={2001},
  volume={154 1-2},
  pages={124-34}
}
Quinine is a well-known ototoxic drug which may affect portions of the auditory system with different biochemical effects, causing reversible hearing loss and tinnitus. Recent investigations indicate that quinine at high concentrations can act directly on cochlear outer hair cells to affect their motility and the mechanical response of the basilar membrane. This study aimed to investigate the effect of quinine on the electromotility of outer hair cells in vivo by means of measuring the… CONTINUE READING

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