Quinine and Caffeine Effects on 45Ca Movements in Frog Sartorius Muscle

  title={Quinine and Caffeine Effects on 45Ca Movements in Frog Sartorius Muscle},
  author={Allen Isaacson and Alexander Sandow},
  journal={The Journal of General Physiology},
  pages={2109 - 2128}
1 mM caffeine, which produces only twitch potentiation and not contracture in frog sartorius muscle, increases both the uptake and release of (45)Ca in this muscle by about 50 %, thus acting like higher, contracture-producing concentrations but less intensely. Quinine increases the rate of release of (45)Ca from frog sartorius but not from the Achilles tendon. The thresholds for the quinine effect on (45)Ca release and contracture tension are about 0.1 and 0.5 mM, respectively, at pH 7.1… CONTINUE READING


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