Quinidine inhibition of debrisoquine S(+)-4- and 7-hydroxylations in Chinese of different CYP2D6 genotypes.

@article{Bertilsson1993QuinidineIO,
  title={Quinidine inhibition of debrisoquine S(+)-4- and 7-hydroxylations in Chinese of different CYP2D6 genotypes.},
  author={L. Bertilsson and C. Meese and Q. Yue and M. Dahl and M. Ingelman-Sundberg and I. Johansson and J. S{\"a}we and M. Eichelbaum},
  journal={Pharmacogenetics},
  year={1993},
  volume={3 2},
  pages={
          94-100
        }
}
Pronounced differences in the CYP2D6 gene between Chinese and Caucasians have previously been described. There was a low frequency of detrimental mutations in the Chinese CYP2D6 gene causing the poor metabolizer (PM) phenotype. In contrast to Caucasians where the Xba I 44 kb allele is almost always associated with the PM phenotype, Chinese with the 44/44 kb RFLP pattern are extensive metabolizers (EM). In order to evaluate whether the debrisoquine hydroxylation seen in subjects with this… Expand
Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling
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