Quinidine-induced inhibition of transient outward current in cardiac muscle.

  title={Quinidine-induced inhibition of transient outward current in cardiac muscle.},
  author={Yuji Imaizumi and Wayne R Giles},
  journal={The American journal of physiology},
  volume={253 3 Pt 2},
Quinidine is frequently used as a class I antiarrhythmic agent in the management of cardiac rhythm disturbances. It depresses the rapid initial depolarization of the action potential by blocking the sodium current, INa. In addition, quinidine increases the duration of the action potential and lengthens the refractory period. We have used a whole cell voltage-clamp technique to study the ionic mechanism underlying the lengthening of the action potential in single cells from the atrium and… CONTINUE READING

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