Quinidine in Short QT Syndrome: An Old Drug for a New Disease

@article{Kaufman2007QuinidineIS,
  title={Quinidine in Short QT Syndrome: An Old Drug for a New Disease},
  author={Elizabeth S. Kaufman},
  journal={Journal of Cardiovascular Electrophysiology},
  year={2007},
  volume={18}
}
  • E. Kaufman
  • Published 1 June 2007
  • Medicine, Biology
  • Journal of Cardiovascular Electrophysiology
Congenital short QT syndrome (SQTS) is a recently described genetically heterogeneous disorder characterized by a very short QT interval and by susceptibility to atrial and ventricular fibrillation.1 Despite rapid advances in understanding the genetic bases of SQTS, much less is known about the spectrum of clinical outcomes and the most appropriate treatments for patients with this disease. Because of the high risk of sudden cardiac death in SQTS, use of the implantable cardioverter… 
Quinidine, a life-saving medication for Brugada syndrome, is inaccessible in many countries.
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  • Medicine
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  • 2007
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Quinidine Depresses the Transmural Electrical Heterogeneity of Transient Outward Potassium Current of the Right Ventricular Outflow Tract Free Wall
TLDR
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Modelling conduction through the Purkinje ventricular junction and the short-QT syndrome associated with HERG mutation in the rabbit ventricles
TLDR
A family of electrophysiologically detailed computer models for rabbit epicardial, midmyocardial and endocardial ventricular myocytes, as well as the rabbit Purkinje fibre cells, are developed to simulate a realistic APD dispersion during conduction through the PVJ under normal conditions and under pathological conditions of the short QT syndrome.
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