Quinidine delays IK activation in guinea pig ventricular myocytes.

@article{Roden1988QuinidineDI,
  title={Quinidine delays IK activation in guinea pig ventricular myocytes.},
  author={Dan M. Roden and Paul B. Bennett and Dirk Snyders and Jeffrey R. Balser and Luc M. Hondeghem},
  journal={Circulation research},
  year={1988},
  volume={62 5},
  pages={1055-8}
}
A major action of the antiarrhythmic agent quinidine is prolongation of cardiac repolarization. In these experiments, the time-dependent effects of quinidine on the delayed rectifier potassium current, IK, a current contributing to cardiac repolarization, were investigated in acutely disaggregated guinea pig ventricular myocytes using the whole-cell recording configuration of the patch-clamp method. The effect of quinidine on IK was dependent on the duration of depolarization. After long (2,000… CONTINUE READING

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