Quinidine blockade of the carbachol-activated nonselective cationic current in guinea-pig gastric myocytes.

@article{Kim1995QuinidineBO,
  title={Quinidine blockade of the carbachol-activated nonselective cationic current in guinea-pig gastric myocytes.},
  author={Sung-Hwan Kim and Seung Cheol Ahn and Insuk So and Ki Whan Kim},
  journal={British journal of pharmacology},
  year={1995},
  volume={115 8},
  pages={1407-14}
}
1. In guinea-pig gastric myocytes isolated from the antral circular layer, stimulation of muscarinic receptors by carbachol (CCh) induces a cationic current (ICCh) which is known as the main mechanism of depolarization induced by muscarinic stimulation. 2. We tested the effects of a number of ion channel blockers on ICCh and focused upon quinidine which was a highly potent blocker. Externally applied quinidine suppressed ICCh (IC50 = 0.25 microM) in a reversible and voltage-dependent manner… CONTINUE READING