Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine.

@article{Speirs1986QuinidineAT,
  title={Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine.},
  author={C. Speirs and S. Murray and A. Boobis and C. E. Seddon and D. Davies},
  journal={British journal of clinical pharmacology},
  year={1986},
  volume={22 6},
  pages={
          739-43
        }
}
Quinidine and its diastereoisomer quinine were tested in vitro for their effect on the 4-hydroxylation of debrisoquine, the O-deethylation of phenacetin and the 1'-hydroxylation of bufuralol, by human liver microsomal samples; quinidine was studied for its effect on debrisoquine 4-hydroxylation in vivo. Quinidine was a potent inhibitor of the 4-hydroxylation of debrisoquine and the 1'-hydroxylation of bufuralol, with IC50 values of 0.7 and 0.2 microM, being around 100 times more potent in this… Expand
Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine
Quinidine but not quinine inhibits in man the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase
Selective in vivo inhibition by quinidine of methoxyphenamine oxidation in rat models of human debrisoquine polymorphism.
4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.
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