Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists.

@article{Mosley2010Quinazolin4oneDA,
  title={Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists.},
  author={Cara A Mosley and Timothy M. Acker and Kasper B Hansen and Praseeda Mullasseril and Karen T Andersen and Phuong Le and Kimberly M. Vellano and Hans Br{\"a}uner-Osborne and Dennis C Liotta and Stephen F Traynelis},
  journal={Journal of medicinal chemistry},
  year={2010},
  volume={53 15},
  pages={5476-90}
}
We describe a new class of subunit-selective antagonists of N-methyl D-aspartate (NMDA)-selective ionotropic glutamate receptors that contain the (E)-3-phenyl-2-styrylquinazolin-4(3H)-one backbone. The inhibition of recombinant NMDA receptor function induced by these quinazolin-4-one derivatives is noncompetitive and voltage-independent, suggesting that this family of compounds does not exert action on the agonist binding site of the receptor or block the channel pore. The compounds described… CONTINUE READING

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