Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice.

@article{Watson2014QuinaprilTA,
  title={Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice.},
  author={Anna M. D. Watson and Jiaze Li and Dian Samijono and Angelika Bierhaus and Merlin C Thomas and Karin Jandeleit-Dahm and Mark Emmanuel Cooper},
  journal={Atherosclerosis},
  year={2014},
  volume={235 2},
  pages={444-8}
}
OBJECTIVE/RATIONALE Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA. METHODS Diabetic (5 × 55 mg/kg streptozotocin daily) and non-diabetic male RAGE/apolipoprotein E double knockout (RAGE/apoE DKO) mice were treated with quinapril (30 mg/kg/day) for 20 weeks. At the end of the study aortic plaques were assessed… CONTINUE READING