Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation.

@article{Gorbachev2007QuinacrineIT,
  title={Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation.},
  author={Anton V. Gorbachev and Alexander V Gasparian and Katerina V Gurova and Andrei V. Gudkov and R. L. Heckaman Mark D. Fairchild},
  journal={European journal of immunology},
  year={2007},
  volume={37 8},
  pages={2257-67}
}
Quinacrine (QC) is an anti-inflammatory drug that has been used for the treatment of malaria and rheumatoid diseases. The mechanism(s) underlying the anti-inflammatory activity of QC remains poorly understood. We recently reported the QC-mediated inhibition of the NF-kappaB pathway using an in vitro model. To test this potential mechanism in vivo, we used the contact hypersensitivity response (CHS) to chemical allergen sensitization and challenge in mice as a model of skin inflammation. The… CONTINUE READING
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