Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.

@article{Wong2009QuinacrineAA,
  title={Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.},
  author={Iris L. K. Wong and Kin-Fai Chan and Yunzhe Zhao and Tak Hang Chan and Larry Ming Cheung Chow},
  journal={The Journal of antimicrobial chemotherapy},
  year={2009},
  volume={63 6},
  pages={
          1179-90
        }
}
OBJECTIVES The aim of this study was to investigate the synergistic effect of quinacrine and a novel apigenin dimer (compound 9d) on reversing pentamidine resistance of Leishmania parasites. METHODS Pentamidine-resistant cell lines, LePentR50 and LdAG83PentR50, were generated by gradually increasing pentamidine pressure on wild-type promastigotes. We tested the effects of different combinations of quinacrine and an apigenin dimer on modulating the pentamidine resistance levels of LePentR50… CONTINUE READING

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