Quinacrine affinity of endocrine cell systems containing dense core vesicles as visualized by fluorescence microscopy

@article{lund1979QuinacrineAO,
  title={Quinacrine affinity of endocrine cell systems containing dense core vesicles as visualized by fluorescence microscopy},
  author={Dr. M. {\AA}lund and Lars Olson},
  journal={Cell and Tissue Research},
  year={1979},
  volume={204},
  pages={171-186}
}
Intravenous injections of low amounts of the fluorescent antimalarial acridine derivative quinacrine into rats and mice lead to selective high affinity binding of the drug, which can be visualized by fluorescence microscopy, to several hormone-producing cell systems. Injection of 1 mg/kg causes strong drug accumulation in the granules of renin-producing… CONTINUE READING