Quinacrine Hydrochloride Pellets: Preliminary Data on a Nonsurgical Method of Female Sterilization

@article{Zipper1980QuinacrineHP,
  title={Quinacrine Hydrochloride Pellets: Preliminary Data on a Nonsurgical Method of Female Sterilization},
  author={J A Zipper and Lynda Painter Cole and Alfredo Goldsmith and Robert G. Wheeler and M Rivera},
  journal={International Journal of Gynecology \& Obstetrics},
  year={1980},
  volume={18}
}
The efficacy of transcervical insertions of quinacrine hydrochloride pellets to produce tubal occlusion has been evaluated in a study of 139 women in Santiago, Chile. At one year, the pregnancy rate was 3.1%, an acceptable rate for a nonsurgical method of female sterilization. 
Nonsurgical Female Sterilization
  • L. Laufe, L. Cole
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 1980
TLDR
Using an IUD vector to deliver the quinacrine, tubal occlusion can be achieved with a reduction in total dosage and with one insertion instead of the three necessary with the solution and pellet methods.
Four-year follow-up of insertion of quinacrine hydrochloride pellets as a means of nonsurgical female sterilization.
TLDR
The results of this study indicate that intrauterine insertion of quinacrine pellets can be a safe, effective nonsurgical sterilization procedure.
Studies of quinacrine and of tetracycline for non-surgical female sterilization
  • B. Mullick, S. Mumford, E. Kessel
  • Medicine
    Advances in contraception : the official journal of the Society for the Advancement of Contraception
  • 1987
The transcervical quinacrine pellet method developed by Zipper and co-workers is potentially a much needed safe, inexpensive, and effective non-surgical method of female sterilization. This method
Transcervical quinacrine sterilization: clinical experience.
  • D. Sokal, J. Zipper, T. King
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 1995
TLDR
The short-term safety of transcervical quinacrine appears to be better than surgical sterilization, but it is less effective, especially among women under 35, and there are virtually no data on its reversibility.
Quinacrine pellet nonsurgical female sterilization in Wonosobo, Indonesia.
TLDR
Intrauterine insertion of quinacrine pellets is a safe and acceptably effective method of nonsurgical female sterilization.
Nonsurgical female sterilization with quinacrine pellets: Malaysian experience.
  • H. Arshat, Ang Eng Suan, Kwa Siew Kim
  • Medicine
    Malaysian journal of reproductive health : a publication of the Reproductive Research Centre of the National Population and Family Development Board, Malaysia
  • 1987
TLDR
Evaluated the effectiveness of intrauterine quinacrine pellet application as a method of female sterilization on the basis of 1 year follow-up and the safety, cost, acceptability and ease of administration of this procedure, finding morbidity is low.
00 000 Quinacrine Sterilizations
100 000 quinacrine nonsurgical female sterilizations have been completed over the past decade involving transcervical insertion of quinacrine (252 mg) as pellets by one, two or three monthly
Quinacrine nonsurgical female sterilization: a reassessment of safety and efficacy.
TLDR
The relative safety and efficacy of surgical methods and nonsurgical quinacrine pellet methods of female sterilization have been reassessed and the absence of increased risk of ectopic pregnancy among quinzine pellet method failures has been noted.
31781 cases of non-surgical female sterilisation with quinacrine pellets in Vietnam
TLDR
This method is safe and acceptably effective for female sterilisation and an estimated 242 maternal deaths will be averted by these 31,781 sterilizations.
Quinacrine sterilization: a retrospective
  • J. Zipper, E. Kessel
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2003
TLDR
A standard protocol of 252 mg in seven 36 mg pellets placed at the uterine fundus on two occasions a month apart has now been widely used with considerable evidence for safety and efficacy and protection is greater than 98% at 2 years of use.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 11 REFERENCES
Transvaginal chemical sterilization: clinical use of quinacrine plus potentiating adjuvants.
TLDR
The most effective treatment regimen, quinacrine + xylocaine, with and without epinephrine, after the second instillation had an obstruction rate of 94%.
Human fertility control by transvaginal application of quinacrine on the fallopian tube.
TLDR
The preliminary observations with this nonspecific type of caustic material suggest that they should be dissolved in ethanol before their instillation, and their combination with ethanol enhances, and possibly hastens, the coagulation of the endometrial proteins, thus reducing to a minimum the quantity of caUSTic material which may escape through the fallopian tube into the peritoneal cavity.
Alterations in fertility induced by unilateral intrauterine instillation of cytotoxic compounds in rats.
Abstract Cytotoxic agents, cadmium, iodoacetate, thio-TEPA, podophyllin, colchicine, and alcohol, were instilled in one uterine horn of the rat to observe their subsequent effect on fertility.
CREATED FROM SCANNED DOCUMENT, PLEASE REFER TO ORIGINAL
  • CREATED FROM SCANNED DOCUMENT, PLEASE REFER TO ORIGINAL
  • 1980
Transvaginal chemical sterilization
  • Contraception I
  • 1975
A (eds): The Pharmacologic Basis of Therapeutics, 4th ed, p 1081
  • USA IntJ Gynaecol Obstet
  • 1970
The Pharmacologic Basis of Therapeutics , 4 th ed , p 1081
  • 1970
Alteration in fertility induced by unilateral intrauterine instillation of cytotoxic corn - . pounds in rats
  • Am J Obstet Gynecol
  • 1968
The Pharmacologic Basis of Therapeutics
  • The iMacmillan Co
  • 1081
Address for reprints: Information Coordinator International Fertility Research Program Research Triangle Park, NC 27709 USA ht
  • Address for reprints: Information Coordinator International Fertility Research Program Research Triangle Park, NC 27709 USA ht
...
1
2
...