Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4+ T cell responsiveness to antigen.

@article{Dooms1998QuiescenceinducingAA,
  title={Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4+ T cell responsiveness to antigen.},
  author={Hans Dooms and Marjory Desmedt and Sabine Vancaeneghem and Pieter Rottiers and Vera Goossens and Walter Fiers and Johan Grooten},
  journal={Journal of immunology},
  year={1998},
  volume={161 5},
  pages={2141-50}
}
IL-15 shows functional redundancy with IL-2 due to its usage of the beta and gamma c subunit of the IL-2R. Yet, the requirement of IL-15 for an IL-15R alpha chain for high affinity interaction and the separate cellular sources of IL-2 and IL-15 suggest divergent activities for both cytokines. We compared the growth-inducing and proapoptotic or antiapoptotic activities of IL-15 and IL-2 on mature CD4+ T lymphocytes in the presence or absence of TCR occupancy. We found that the nature of IL-15… CONTINUE READING