Quiescence induced by iron challenge protects neuroblastoma cells from oxidative stress.

@article{Mura2006QuiescenceIB,
  title={Quiescence induced by iron challenge protects neuroblastoma cells from oxidative stress.},
  author={Casilda V. Mura and Ricardo Delgado and Pabla Aguirre and Juan Carlos Bacigalupo and Marco T. Nu{\~n}ez},
  journal={Journal of neurochemistry},
  year={2006},
  volume={98 1},
  pages={
          11-9
        }
}
The brain uses massive amounts of oxygen, generating large quantities of reactive oxygen species (ROS). Because of its lipid composition, rich in unsaturated fatty acids, the brain is especially vulnerable to ROS. Furthermore, oxidative damage in the brain is often associated with iron, which has pro-oxidative properties. Iron-mediated oxidative damage in the brain is compounded by the fact that brain iron distribution is non-uniform, being particularly high in areas sensitive to… CONTINUE READING
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