Quick serological detection of a cancer biomarker with an agglutinated supramolecular glycoprobe.

@article{He2015QuickSD,
  title={Quick serological detection of a cancer biomarker with an agglutinated supramolecular glycoprobe.},
  author={Xiao-Peng He and Xi-Le Hu and Hong-ying Jin and Jiemin Gan and Huili Zhu and Jia Li and Yi-Tao Long and He Tian},
  journal={Analytical chemistry},
  year={2015},
  volume={87 17},
  pages={9078-83}
}
While serology represents the forefront technique for cancer diagnosis, current clinical methods for the detection of serum biomarkers have flaws in terms of the need of complicated manipulations, long analytical time, and high cost. Here, we develop a supramolecular glycoprobe for the quick serological detection of a cancer biomarker. The probe formed by agglutination between self-assembled glyco-gold nanoparticles and a lectin shows subtle optical variations upon the competitive recognition… CONTINUE READING