Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase.

@article{Boland2009QueuosineFI,
  title={Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase.},
  author={Coil{\'i}n Boland and Patti Hayes and Ismael Santa-Mar{\'i}a and Susumu Nishimura and Vincent P. Kelly},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 27},
  pages={18218-27}
}
tRNA guanine transglycosylase (TGT) enzymes are responsible for the formation of queuosine in the anticodon loop (position 34) of tRNA(Asp), tRNA(Asn), tRNA(His), and tRNA(Tyr); an almost universal event in eubacterial and eukaryotic species. Despite extensive characterization of the eubacterial TGT the eukaryotic activity has remained undefined. Our search of mouse EST and cDNA data bases identified a homologue of the Escherichia coli TGT and three spliced variants of the queuine tRNA guanine… CONTINUE READING
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