Quetiapine for insomnia: A review of the literature.
@article{Anderson2014QuetiapineFI, title={Quetiapine for insomnia: A review of the literature.}, author={Sarah L. Anderson and Joseph P. Vande Griend}, journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists}, year={2014}, volume={71 5}, pages={ 394-402 } }
PURPOSE
The safety and efficacy of quetiapine for the treatment of insomnia in adults are reviewed.
SUMMARY
Quetiapine was developed for the treatment of psychiatric disorders, but its antagonism of histamine H1- and serotonin type 2A receptors has the added effect of causing sedation. As such, quetiapine is widely used off-label as a treatment for insomnia. Due to quetiapine's potential adverse effects, guidelines for the treatment of insomnia have recommended the drug's use only in patients…
82 Citations
Quetiapine as a Potential Treatment for Insomnia: The Road Ahead
- Psychology, MedicineChronobiology in Medicine
- 2022
Quetiapine is recommended for treating insomnia in the elderly not only because of the vulnerability and risk of side effects associated with sedative-hypnotics, but also because of its sedative action.
Prescription Dose Analysis of Quetiapine in the Elderly and Insomnia
- Medicine, PsychologyChronobiology in Medicine
- 2021
In the case of primary insomnia, quetiapine dose prescribed in the elderly patient group is higher than that in the non-elderly patient group, which is a relatively low dose prescribed compared to schizophrenia and bipolar disorder.
Evaluation of the use of low-dose quetiapine and the risk of metabolic consequences: A retrospective review
- Medicine, PsychologyThe mental health clinician
- 2016
There may be negative metabolic consequences with the use of low-dose quetiapine in patients with sleep disturbances and routine prescribing of low doses for sleep as a first-line medication should be avoided.
Does Combining Aripiprazole With Other Antipsychotics Worsen Psychosis?
- Psychology, MedicineJournal of clinical psychopharmacology
- 2015
There is a clear rise in the OL use of low doses of quetiapine and mirtazapine in psychiatric patients and in individuals without serious psychiatric comorbidity, presumably to improve night-time sleep.
Pharmacologic Treatment Options for Insomnia in Patients with Schizophrenia
- Medicine, PsychologyMedicines
- 2018
Overall, this review confirmed that there are a few evidence-based options to treat insomnia in patients with schizophrenia, including selecting a more sedating second-generation antipsychotic such as paliperidone, or adding melatonin or eszopiclone.
Quetiapine withdrawal: A systematic review
- Psychology, MedicineThe Australian and New Zealand journal of psychiatry
- 2020
Clinicians should be alert to the possibility of quetiapine withdrawal in individuals who present with somatic symptoms or choreiform movements, and large prospective studies are required to clarify this association.
Pharmacotherapeutic options for treatment of insomnia
- Psychology, Biology
- 2014
The pharmacotherapy of insomnia and the drugs under development for the treatment of insomnia are described and potential agents under investigations are targeting mechanisms and pathways including histamine (H 1 ) receptor, melatonin, and orexin receptors.
Off-Label Prescriptions of Low-Dose Quetiapine and Mirtazapine for Insomnia in The Netherlands
- Medicine, PsychologyJournal of clinical psychopharmacology
- 2015
There are only limited data supporting the use of low doses of quetiapine in patients suffering from insomnia, and case reports describe restless legs syndrome, akathisia, and hepatotoxicity for low-dose quetuapine and mirtazapine.
Treatment of chronic insomnia disorder in menopause: evaluation of literature
- Medicine, PsychologyMenopause
- 2015
Although a variety of interventions are shown to be helpful in improving sleep in menopause, there is a need for well-designed head-to-head trials with uniform outcome measures.
References
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