Quetiapine for insomnia: A review of the literature.

@article{Anderson2014QuetiapineFI,
  title={Quetiapine for insomnia: A review of the literature.},
  author={Sarah L Anderson and Joseph P. Vande Griend},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  year={2014},
  volume={71 5},
  pages={
          394-402
        }
}
  • Sarah L Anderson, Joseph P. Vande Griend
  • Published 1 March 2014
  • Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
PURPOSE The safety and efficacy of quetiapine for the treatment of insomnia in adults are reviewed. SUMMARY Quetiapine was developed for the treatment of psychiatric disorders, but its antagonism of histamine H1- and serotonin type 2A receptors has the added effect of causing sedation. As such, quetiapine is widely used off-label as a treatment for insomnia. Due to quetiapine's potential adverse effects, guidelines for the treatment of insomnia have recommended the drug's use only in patients… 
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References

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Safety of Low Doses of Quetiapine When Used for Insomnia
TLDR
Using low-dose quetiapine for insomnia is not recommended based on limited data and potential safety concerns, and serious adverse events identified included fatal hepatotoxicity, restless legs syndrome, akathisia, and weight gain.
Quetiapine for Insomnia in Parkinson Disease: Results From an Open-Label Trial
TLDR
It is suggested that quetiapine may be a safe and effective treatment of insomnia in PD patients and double-blind studies will probably confirm these findings.
Metabolic Consequences of Using Low-Dose Quetiapine for Insomnia in Psychiatric Patients
TLDR
Despite the low doses typically used when quetiapine is prescribed for insomnia, metabolic adverse effects can occur and should be considered in the overall benefit to risk analysis.
Quetiapine for primary insomnia: a double blind, randomized controlled trial.
TLDR
Quetiapine at 25 mg at night did show a trend for improvement of TST and reduced SL in primary insomnia with few side effects but not reaching statistical significance, and a study with a larger sample size is needed to demonstrate its efficacy.
Quetiapine in the Treatment of Sleep Disturbances Associated with Addictive Conditions: A Retrospective Study
TLDR
The classical option of using sedating–hypnotic drugs to treat insomnia in polydrug users presents objections: the tolerance associated to high doses of benzodiacepines chronic abuse in many drug addicts obliges the clinician to use high doses in acute detoxificaton and the following de-habituation.
Quetiapine augmentation in treatment-resistant depression: a naturalistic study
TLDR
Preliminary data indicate that quetiapine add-on therapy appears to have beneficial effects in the treatment of patients with TRD.
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TLDR
Mixed-effects regression showed that quetiapine plus fluoxetine did not achieve 50% reduction in the Montgomery–Åsberg Depression Rating Scale score or improvement in Hamilton Anxiety Scale, Clinical Global Improvement (CGI)-Severity, and CGI-Improvement scores sooner than the fluxetine plus placebo group; however both groups improved in all scores over time.
Patterns of quetiapine use in psychiatric inpatients: an examination of off-label use.
TLDR
The most common diagnoses in patients receiving standing dose quetiapine were depressive disorders, followed by substance-related, bipolar, and psychotic disorders, and the most common prn dose was 50 mg, given for agitation or insomnia.
Quetiapine monotherapy in the treatment of depressive episodes of bipolar I and II disorder: Improvements in quality of life and quality of sleep.
TLDR
Quetiapine monotherapy is effective in improving impairment in important aspects of life that accompany improvements in depressive symptoms in patients with acute bipolar depression.
A double-blind, placebo-controlled study of quetiapine and paroxetine as monotherapy in adults with bipolar depression (EMBOLDEN II).
TLDR
Quetiapine (300 or 600 mg/d), but not paroxetine, was more effective than placebo for treating acute depressive episodes in bipolar I and II disorder.
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