Quetiapine Abuse Fourteen Years Later: Where Are We Now? A Systematic Review

  title={Quetiapine Abuse Fourteen Years Later: Where Are We Now? A Systematic Review},
  author={Alessandro Emiliano Vento and Georgios Demetrios Kotzalidis and Marta Cacciotti and Gabriele Duccio Papanti and Laura Orsolini and Chiara Rapinesi and Valeria Savoja and Giuseppa Calabr{\`o} and Antonio Del Casale and Daria Piacentino and Matteo Caloro and Paolo Girardi and Fabrizio Schifano},
  journal={Substance Use \& Misuse},
  pages={304 - 313}
Abstract Background: Quetiapine, an atypical antipsychotic endowed with weak dopamine antagonist, potent 5-HT2A-blocking, partial 5-HT1A-agonist, anti-H1 histamine, adrenolytic, and sigma1 receptor agonist activities, since an original 2004 report is increasingly misused. Although some of its pharmacodynamics might explain some motives for voluptuary use, most of its actions are directed at setting-off those motives. Hence, it is possible that its popularity in special populations is due to the… 
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Focus on Clozapine Withdrawal- and Misuse-Related Cases as Reported to the European Medicines Agency (EMA) Pharmacovigilance Database
Previous suggestions about the possibility of a clozapine discontinuation/withdrawal occurrence are supported, but further studies are needed, and the misuse/abuse cases here identified might be difficult to interpret, given the lack of studies highlighting the possible recreational use of clozAPine.
Quetiapine, Misuse and Dependency: A Case-Series of Questions to a Norwegian Network of Drug Information Centers
The case series from the Norwegian network of drug information centres reflects that quetiapine frequently involves clinical narratives of a history of addiction, polypharmacy or insomnia (off-label use), however, the case series did not reveal new information about the drug’s addictive potential.
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Identification and Quantification of Antipsychotics in Blood Samples by LC-MS-MS: Case Reports and Data from Three Years of Routine Analysis.
It is pointed that antipsychotics are an increasingly prevalent class of drugs and must be measured not only in toxic concentrations but also in therapeutic levels in postmortem cases therefore, the importance of a sensitive method to cover the low therapeutic range in which AP are usually present.
Tapering opioids: a comprehensive qualitative review.
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Understanding the use of prescription and OTC drugs in obtaining illicit highs and the pharmacist role in preventing abuse
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A Learning Health System Framework to Operationalize Health Data to Improve Quality Care: An Australian Perspective
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Quetiapine in the Treatment of Psychosis
  • G. Laux
  • Psychology
  • 2021


[Misuse and abuse of quetiapine].
The paper presents and discusses the reports of quetiapine misuse, abuse, and even mental addiction, as well as symptoms similar to the so-called discontinuation syndrome, often mixed with withdrawal syndrome occurring in the course of addiction.
Quetiapine Misuse and Abuse: Is it an Atypical Paradigm of Drug Seeking Behavior?
In the absence of a definitive mechanism of action of quetiapine's reinforcing properties, it is imperative to gather robust evidence to support or refute increasing off-label use of AAs.
[Quetiapine in substance use disorders, abuse and dependence possibility: a review].
  • Serap Erdoğan
  • Psychology, Medicine
    Turk psikiyatri dergisi = Turkish journal of psychiatry
  • 2010
This review aimed to present all published case reports on quetiapine abuse and to discuss the possible mechanisms that underlie its abuse and dependence.
Abuse of Second - Generation Antipsychotics: What Prescribers Need to Know
Although outpatient misuse of quetiapine is common, abuse in correctional settings also is becoming more frequent, and Clinicians must differentiate inmates who have legitimate psychiatric symptoms that require antipsychotic treatment from those who are malingering to obtain the drug.
Misuse and Associated Harms of Quetiapine and Other Atypical Antipsychotics.
The evidence behind the misuse of atypical antipsychotic agents with a focus of quetiapine is explored, the factors that may be driving this misuse are considered, and interventions at a prescriber and systems level are suggested to reduce the risk of this misuse.
Quetiapine: treatment for substance abuse and drug of abuse.
  • M. Hanley, G. A. Kenna
  • Psychology, Medicine
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2008
Small-scale studies provide some evidence that quetiapine may benefit patients diagnosed with a mental illness who are also dependent on cocaine, amphetamines, or both, though more rigorous studies are needed.
Quetiapine abuse and dependence in psychiatric patients: a systematic review of 25 case reports in the literature
Quetiapine is likely to be abused by male psychiatric patients in their mid-thirties and less than 50% of them having positive history of substance abuse/dependence, suggesting close monitoring for drug misuse is needed in the course of the entire treatment period.
The role of antihistaminic effects in the misuse of quetiapine: A case report and review of the literature
Abuse of Prescription Drugs in the Context of Novel Psychoactive Substances (NPS): A Systematic Review
A systematic review of medications which have emerged as being used recreationally, either on their own or in combination with NPS, finds that among gabapentinoids, pregabalin may present with higher addictive liability levels than gabAPentin, with pregABalin being mostly identified in the context of opioid, polydrug intake.
Quetiapine abuse and dependence: is pharmacokinetics important?
The authors described an interesting case of dependence developing in course of the treatment emphasising the risk of abuse and importance of patient monitoring, and the important issues of pharmacokinetics, drug tolerance and sex of the patient have not been addressed.