Quetiapine, an Atypical Antipsychotic, Is Protective against Autoimmune-Mediated Demyelination by Inhibiting Effector T Cell Proliferation

@inproceedings{Mei2012QuetiapineAA,
  title={Quetiapine, an Atypical Antipsychotic, Is Protective against Autoimmune-Mediated Demyelination by Inhibiting Effector T Cell Proliferation},
  author={Feng Mei and Sheng Guo and Yangtao He and Linyun Wang and Hongkai Wang and Jianqin Niu and Jiming Kong and Xinmin Li and Yu-zhang Wu and Lan Xiao},
  booktitle={PloS one},
  year={2012}
}
Quetiapine (Que), a commonly used atypical antipsychotic drug (APD), can prevent myelin from breakdown without immune attack. Multiple sclerosis (MS), an autoimmune reactive inflammation demyelinating disease, is triggered by activated myelin-specific T lymphocytes (T cells). In this study, we investigated the potential efficacy of Que as an immune-modulating therapeutic agent for experimental autoimmune encephalomyelitis (EAE), a mouse model for MS. Que treatment was initiated on the onset of… CONTINUE READING

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