Questioning the depolarizing effects of GABA during early brain development.

@article{Khakhalin2011QuestioningTD,
  title={Questioning the depolarizing effects of GABA during early brain development.},
  author={Arseny S Khakhalin},
  journal={Journal of neurophysiology},
  year={2011},
  volume={106 3},
  pages={
          1065-7
        }
}
During early brain development, γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, has been thought to be an important source of excitatory neurotransmission. This view, however, was recently challenged by a series of studies that claim that the excitatory effect of GABA is due to non-physiological in vitro experimental conditions. In this article, we aim to summarize results that support and challenge the traditional point of view, and indicate some strong and… Expand
Recent progress in GABAergic excitation from mature brain
  • L. Chung
  • Biology, Medicine
  • Archives of pharmacal research
  • 2012
TLDR
In neural circuit activity, presumed GABAergic excitation was observed in basolateral amygdala during the study of a neuropeptide, cholecystokinin, and it may be implicated in epilepsy or anxiety in the adult brain. Expand
GABAergic Transmission and Chloride Equilibrium Potential Are Not Modulated by Pyruvate in the Developing Optic Tectum of Xenopus laevis Tadpoles
TLDR
Standard glucose-based ACSF is an appropriate extracellular media for in vitro experiments and there is a strong spatial gradient in GABA reversal potential, with immature cells adjacent to the lateral and caudal proliferative zones having more positive reversal potentials. Expand
Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission
TLDR
The morphologies, wiring, and architectures of single synapses of projection neurons in the murine hippocampus that developed in virtually complete absence of vesicular glutamate release are examined, suggesting that glutamatergic neurotransmission is unnecessary for synapse assembly and maintenance. Expand
Emerging themes in GABAergic synapse development
TLDR
This review will provide a detailed overview of the current understanding of GABAergic synapse development with a particular emphasis on assembly of synaptic components, molecular mechanisms of synaptic development, and a subset of human disorders which manifest when GABAergicsynapse development is disrupted. Expand
Thalamic inhibitory circuits and network activity development
TLDR
It is argued that weak inhibitory function in the developing thalamus allows for amplification of thalamocortical activity that supports the generation of early oscillations and drives the developmental acquisition of critical thalamic oscillations. Expand
Differences in developmental changes in GABAergic response between bushy and stellate cells in the rat anteroventral cochlear nucleus
TLDR
The results suggest that GABAergic inhibition functions earlier in bushy than in stellate cells, and that the longer excitatory action of GABA on stellates possibly renders them more vulnerable than bushy cells to excitotoxic substances during early development. Expand
Synaptic activity-induced Ca2+ signaling in avian cochlear nucleus magnocellularis neurons
TLDR
It is found that electrical stimulation applied to the glutamatergic and GABAergic afferent fibers innervating the NM was able to elicit transient [Ca(2+)](i) increases in NM neurons, and the amplitude of the Ca(2+) responses increased with increasing frequency and duration of the electrical stimulation. Expand
GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii
TLDR
Evidence is provided that GABAergic signaling modulates the migratory properties of DC and that T. gondii likely makes use of this pathway for dissemination in the immune system that may be hijacked by intracellular pathogens. Expand
Bio-functional pickles that reduce blood pressure of rats
TLDR
A new type of fermentation bed composed of rice bran and white miso has been successfully developed that contains both GABA and ACE-inhibitory peptides, which is beneficial for pickle business. Expand
Toxoplasma gondii: manipulation of host cell machinery in the journey from intestine to brain
TLDR
GABA signaling modulated the transmigration of DC and that the intracellular pathogen Toxoplasma gondii seizes the GABAergic signaling of DC like a trojan horse mechanism to assure dissemination is concluded. Expand
...
1
2
...

References

SHOWING 1-10 OF 12 REFERENCES
GABA Depolarizes Immature Neocortical Neurons in the Presence of the Ketone Body β-Hydroxybutyrate
TLDR
In vitro, GABA depolarizes immature cells of the upper cortical plate in the presence of the ketone body βHB to support the general concept of an excitatory-to-inhibitory switch of GABA action during early development. Expand
GABA action in immature neocortical neurons directly depends on the availability of ketone bodies
TLDR
By inducing a hyperpolarizing shift in Em and modulating GABA signaling mode, KBs can efficiently control the excitability of neonatal cortical neurons. Expand
Depolarizing Actions of GABA in Immature Neurons Depend Neither on Ketone Bodies Nor on Pyruvate
TLDR
d-BHB does not alter GABA signals even at the high concentrations used by Zilberter and colleagues, whereas pyruvate requires exceedingly high nonphysiological concentrations to exert an effect, and there is no need to alter conventional glucose enriched artificial CSF to investigate GABA signals in the developing brain. Expand
Differences in Cortical versus Subcortical GABAergic Signaling: A Candidate Mechanism of Electroclinical Uncoupling of Neonatal Seizures
TLDR
Regional differences in the ontogeny of Cl(-) transport may explain why seizure activity in the cortex is not suppressed by anticonvulsants that block the transmission of seizure activity through subcortical networks. Expand
Metabolic Control of Vesicular Glutamate Transport and Release
TLDR
An unsuspected link between metabolic state and excitatory neurotransmission through anion-dependent regulation of VGLUT activity is indicated through functional reconstitution of the purified VGLuts into proteoliposomes. Expand
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.
TLDR
It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks. Expand
Spontaneous Network Events Driven by Depolarizing GABA Action in Neonatal Hippocampal Slices are Not Attributable to Deficient Mitochondrial Energy Metabolism
TLDR
The main conclusions of this work are that the inhibitory effect of l-lactate on GDPs is not mediated by mitochondrial energy metabolism, and that glucose at its standard 10 mm concentration is an adequate energy substrate for neonatal neurons in vitro. Expand
Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis.
TLDR
This paper discusses the relationships between availability of energy substrates and neuronal excitability, and suggests that for in vitro studies, it is crucial to optimize the composition of the energy pool in the extracellular milieu. Expand
Activity‐dependent regulation of energy metabolism by astrocytes: An update
TLDR
Very recent experimental evidence as well as theoretical arguments strongly supporting the original astrocyte‐neuron lactate shuttle concept are reviewed, with new perspectives offered by the application of this concept. Expand
...
1
2
...