Questioning the depolarizing effects of GABA during early brain development.

@article{Khakhalin2011QuestioningTD,
  title={Questioning the depolarizing effects of GABA during early brain development.},
  author={Arseny S Khakhalin},
  journal={Journal of neurophysiology},
  year={2011},
  volume={106 3},
  pages={
          1065-7
        }
}
During early brain development, γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, has been thought to be an important source of excitatory neurotransmission. This view, however, was recently challenged by a series of studies that claim that the excitatory effect of GABA is due to non-physiological in vitro experimental conditions. In this article, we aim to summarize results that support and challenge the traditional point of view, and indicate some strong and… Expand
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This review will provide a detailed overview of the current understanding of GABAergic synapse development with a particular emphasis on assembly of synaptic components, molecular mechanisms of synaptic development, and a subset of human disorders which manifest when GABAergicsynapse development is disrupted. Expand
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It is argued that weak inhibitory function in the developing thalamus allows for amplification of thalamocortical activity that supports the generation of early oscillations and drives the developmental acquisition of critical thalamic oscillations. Expand
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The results suggest that GABAergic inhibition functions earlier in bushy than in stellate cells, and that the longer excitatory action of GABA on stellates possibly renders them more vulnerable than bushy cells to excitotoxic substances during early development. Expand
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It is found that electrical stimulation applied to the glutamatergic and GABAergic afferent fibers innervating the NM was able to elicit transient [Ca(2+)](i) increases in NM neurons, and the amplitude of the Ca(2+) responses increased with increasing frequency and duration of the electrical stimulation. Expand
GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii
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Evidence is provided that GABAergic signaling modulates the migratory properties of DC and that T. gondii likely makes use of this pathway for dissemination in the immune system that may be hijacked by intracellular pathogens. Expand
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A new type of fermentation bed composed of rice bran and white miso has been successfully developed that contains both GABA and ACE-inhibitory peptides, which is beneficial for pickle business. Expand
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GABA signaling modulated the transmigration of DC and that the intracellular pathogen Toxoplasma gondii seizes the GABAergic signaling of DC like a trojan horse mechanism to assure dissemination is concluded. Expand
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