Questioning the Methodologic Superiority of ‘Placebo’ Over ‘Active’ Controlled Trials

@article{Howick2009QuestioningTM,
  title={Questioning the Methodologic Superiority of ‘Placebo’ Over ‘Active’ Controlled Trials},
  author={J. Howick},
  journal={The American Journal of Bioethics},
  year={2009},
  volume={9},
  pages={34 - 48}
}
  • J. Howick
  • Published 2009
  • Medicine
  • The American Journal of Bioethics
A resilient issue in research ethics is whether and when a placebo-controlled trial (PCT) is justified if it deprives research subjects of a recognized treatment. The clinicians' moral duty to provide the best available care seems to require the use of ‘active’ controlled trials (ACTs) that use an established treatment as a control whenever such a therapy is available. In another regard, ACTs are supposedly methodologically inferior to PCTs. Hence, the moral duty of the clinical researcher to… Expand

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