Questioning antiviral RNAi in mammals

@article{tenOever2017QuestioningAR,
  title={Questioning antiviral RNAi in mammals},
  author={Benjamin R tenOever},
  journal={Nature Microbiology},
  year={2017},
  volume={2}
}
To the Editor — I wish to comment on the central claim made in the article by Li et al., which suggests that mammals elicit a small RNA-mediated response to RNA virus infection in somatic cells1. While our evolutionary past certainly suggests that our ancestors used RNA interference (RNAi) to limit virus replication, with the emergence of vertebrates came a protein-based defence that hinged on the family of interferons (IFNs)2. A question that remains is whether RNAi still represents a… CONTINUE READING
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References

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The Logic of Scientific Discovery (Martino

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