Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk.

@article{Paigen1977QuestionableRO,
  title={Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk.},
  author={Beverly J. Paigen and Hira L. Gurtoo and Jun Minowada and Lorne Houten and Renaud Vincent and Kenneth Paigen and Natalie B. Parker and Elizabeth Adeoye Peyton Allison Calandra Blackburn Mikal Blo Ward and Nancy T. Hayner},
  journal={The New England journal of medicine},
  year={1977},
  volume={297 7},
  pages={346-50}
}
To test whether the genetically determined trait, aryl hydrocarbon hydroxylase inducibility, affects susceptibility to lung cancer, we measured this trait in cultured lymphocytes from a normal population, patients with lung cancer and progeny of such patients. We found very low aryl hydrocarbon hydroxylase activity (19 per cent of normal) in about half the patients with lung cancer. Only part of this activity can be accounted for by reduced cell growth and by reduced protein synthesis. In an… CONTINUE READING

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