Question 2: Does a failure to respond to antipyretics predict serious illness in children with a fever?
@article{King2013Question2D, title={Question 2: Does a failure to respond to antipyretics predict serious illness in children with a fever?}, author={David Anthony King}, journal={Archives of Disease in Childhood}, year={2013}, volume={98}, pages={644 - 646} }
You are a senior house officer (SHO) working in a busy district general hospital. A 9-month-old boy is brought in by his parents with a fever of 2 days duration. There is no obvious focus but the child appears well. A urine dipstick is negative. When reviewing the child, the registrar is concerned to learn that the fever has not responded to paracetamol (acetaminophen). You wonder if there is any evidence that a febrile child is more likely to have a serious illness if their fever fails to…
5 Citations
Fever in Children: Pearls and Pitfalls Please share how this access benefits you. Your story matters
- Medicine
- 2017
The epidemiology and measurement of fever, the meaning of fever and associated clinical signs in children of different ages and under special conditions are reviewed, including fever in children with cognitive impairment, recurrent fevers, and fever of unknown origin.
Fever in Children: Pearls and Pitfalls
- MedicineChildren
- 2017
The epidemiology and measurement of fever, the meaning of fever and associated clinical signs in children of different ages and under special conditions are reviewed, including fever in children with cognitive impairment, recurrent fevers, and fever of unknown origin.
Il sintomo febbre: l'interpretazione e la corretta gestione
- MedicineMedico e Bambino
- 2022
Current evidence is shown on the role of fever, the most correct methods for its measurement, the reasonable use of drugs for the symptomatic control of fever and the approach to be followed in the management of fever in the child aged less than 5 years.
Fever response to ibuprofen in viral and bacterial childhood infections.
- MedicineThe American journal of emergency medicine
- 2020
Paracetamol: a focus for the general pediatrician
- MedicineEuropean Journal of Pediatrics
- 2013
Although frequently prescribed, the concept of “effect compartment concentration” and the possible co-factors that could cause toxicity at recommended doses are not familiar to all pediatricians and general practitioners.
References
SHOWING 1-10 OF 13 REFERENCES
Childhood fever: correlation of diagnosis with temperature response to acetaminophen.
- MedicinePediatrics
- 1987
Relationship of bacteremia to antipyretic therapy in febrile children
- MedicinePediatric emergency care
- 1987
It is concluded that lack of fever response to antipyretics is not a clinical marker for bacteremia in children.
Temperature response to acetaminophen and risk of occult bacteremia: a case-control study.
- Medicine, BiologyThe Journal of pediatrics
- 1989
Temperature response to antipyretic therapy in children: relationship to occult bacteremia.
- MedicineThe American journal of emergency medicine
- 1985
Correlating Changes in Body Temperature With Infectious Outcome in Febrile Children Who Receive Acetaminophen
- MedicineClinical pediatrics
- 1993
Highly febrile young children with and without invasive bacterial infections who receive a therapeutic dose of acetaminophen experience a significant temperature drop after 60 to 90 min but do not commonly defervesce to an afebrile state.
Diagnostic tests for occult bacteremia: temperature response to acetaminophen versus WBC count.
- MedicineThe American journal of emergency medicine
- 1994
FPIN's Clinical Inquiries. Aspirin use in children for fever or viral syndromes.
- MedicineAmerican family physician
- 2009
Aspirin use in children younger than 19 years should be limited to diseases in which aspirin has a proven benefit, such as Kawasaki disease and the juvenile arthritides.
Fever response to acetaminophen in viral vs. bacterial infections.
- MedicineThe Pediatric infectious disease journal
- 1987
There is no correlation between a child's fever response to acetaminophen and the etiology of the fever, and the difference was found to be statistically insignificant.
Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial
- MedicineBMJ : British Medical Journal
- 2008
Parents, nurses, pharmacists, and doctors wanting to use medicines to supplement physical measures to maximise the time that children spend without fever should use ibuprofen first and consider the relative benefits and risks of using paracetamol plus ib uprofen over 24 hours.
Severity of disease correlated with fever reduction in febrile infants.
- Medicine, BiologyPediatrics
- 1989
It was concluded that clinical improvement with defervescence is not a reliable indicator of the presence of occult bacteremia, and routine administration of acetaminophen may interfere with the clinical evaluation by the physician.