Quest for correlates of protection against tuberculosis.

  title={Quest for correlates of protection against tuberculosis.},
  author={Kamlesh Bhatt and Sheetal Verma and Jerrold J. Ellner and Padmini Salgame},
  journal={Clinical and vaccine immunology : CVI},
  volume={22 3},
A major impediment to tuberculosis (TB) vaccine development is the lack of reliable correlates of immune protection or biomarkers that would predict vaccine efficacy. Gamma interferon (IFN-γ) produced by CD4(+) T cells and, recently, multifunctional CD4(+) T cells secreting IFN-γ, tumor necrosis factor (TNF), and interleukin-2 (IL-2) have been used in vaccine studies as a measurable immune parameter, reflecting activity of a vaccine and potentially predicting protection. However, accumulating… CONTINUE READING
Highly Cited
This paper has 44 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
22 Extracted Citations
100 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 22 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 100 references

Similar Papers

Loading similar papers…