Quest for correlates of protection against tuberculosis.

@article{Bhatt2015QuestFC,
  title={Quest for correlates of protection against tuberculosis.},
  author={Kamlesh Bhatt and Sheetal Verma and Jerrold J. Ellner and Padmini Salgame},
  journal={Clinical and vaccine immunology : CVI},
  year={2015},
  volume={22 3},
  pages={258-66}
}
A major impediment to tuberculosis (TB) vaccine development is the lack of reliable correlates of immune protection or biomarkers that would predict vaccine efficacy. Gamma interferon (IFN-γ) produced by CD4(+) T cells and, recently, multifunctional CD4(+) T cells secreting IFN-γ, tumor necrosis factor (TNF), and interleukin-2 (IL-2) have been used in vaccine studies as a measurable immune parameter, reflecting activity of a vaccine and potentially predicting protection. However, accumulating… CONTINUE READING
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