Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in Leptin-induced Human Umbilical Vein Endothelial Cells (HUVECs)

@inproceedings{Indra2012QuercetinSI,
  title={Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in Leptin-induced Human Umbilical Vein Endothelial Cells (HUVECs)},
  author={Mochamad Rasjad Indra and Satuman Karyono and Retty Ratnawati and Safarina G Malik},
  booktitle={BMC Research Notes},
  year={2012}
}
High concentrations of plasma leptin and the release of pro-inflammatory cytokines in leptin-resistance in obesity have been reported to trigger endothelial dysfunction. The objective of this study was to elucidate the role of quercetin in modulating leptin-induced inflammation as assessed by the levels of Ob-Ra expression, ERK1/2 phosphorylation, NF-kappa B activation and TNF-alpha secretion in umbilical vein endothelial cells (HUVECs) in vitro. HUVECs were exposed to either control levels (0… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
24 Extracted Citations
29 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 24 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 29 references

Leptin at 14 years of age: an ongoing story

  • JM Friedman
  • Am J Clin Nutr 2009,
  • 2009
1 Excerpt

Similar Papers

Loading similar papers…