Quercetin restrains TGF-β1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression.

@article{Feng2018QuercetinRT,
  title={Quercetin restrains TGF-β1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression.},
  author={Jihong Feng and Dalong Song and Siyuan Jiang and Xiaohui Yang and Tingting Ding and Hong Zhang and Junmin Luo and Jun Liao and Qian Yin},
  journal={Biochemical and biophysical research communications},
  year={2018},
  volume={498 1},
  pages={
          132-138
        }
}
Emerging evidence has indicated that transforming growth factor-beta 1 (TGF-β1) induces the epithelial-mesenchymal transition (EMT) in cancer cells, thus promoting their motility and invasiveness. Quercetin, a member of the polyphenolic flavonoid family, has been reported to display anticancer activity against a broad range of cancer cell types. Indeed, numerous studies have shown the cancer preventive effects and molecular mechanisms of quercetin in vitro using diverse cell model systems… CONTINUE READING