Quercetin relaxes guinea pig gallbladder strips.

  title={Quercetin relaxes guinea pig gallbladder strips.},
  author={Loren W. Kline and Edward Karpinski},
  journal={Nutrition research},
  volume={36 10},
The Flavone Luteolin, an Endocrine Disruptor, Relaxed Male Guinea Pig Gallbladder Strips
  • L. Kline
  • Biology, Medicine
    Gastroenterology research
  • 2019
In this study, luteolin relaxed cholecystokinin- or KCl-induced tension by blocking extracellular Ca2+ entry as well as intracellular Ca 2+ release and the actions of PKA are also involved in mediating the lutenolin effect.
Relaxant Activities of Extracts from Uvaria rufa Blume and Caesalpinia sappan L. on Excised Rat’s Prostate Strips
The ethyl acetate from the stems of U. rufa was the most potent in relaxing the prostate smooth muscles, and it may be useful to relieve the urological symptoms caused by benign prostatic hyperplasia (BPH).
2-aminoethyldiphenyl borinate: a multitarget compound with potential as a drug precursor.
The molecular pharmacology of 2-APB supports both its potential to act as a drug and the desirable inclusion of its moieties in new drug development.


Effects of quercetin and rutin on vascular preparations
The mechanical and electrophysiological properties of quercetin and its rutoside, rutin, are investigated in an attempt to clarify how Ca2+ channel activation might be related to the myorelaxing activity.
Vasodilator effects of quercetin in isolated rat vascular smooth muscle.
Gastric relaxation induced by apigenin and quercetin: analysis of the mechanism of action.
Calcitonin gene-related peptide: an inhibitor of guinea pig gallbladder contraction.
Calcitonin gene-related peptide (CGRP) relaxes vascular and intestinal smooth muscle and may in part act directly on the gallbladder smooth muscle to inhibit contraction.
Inhibition of Guinea Pig Intestinal Peristalsis by the Flavonoids Quercetin, Naringenin, Apigenin and Genistein
Naringenin and quercetin inhibit peristalsis by facilitating inhibitory enteric pathways, whereas apigenin and genistein interfere with muscle excitation or excitation-contraction coupling.
Studies with cholecystokinin in vitro. 3. Mechanism of the effect on the isolated rabbit gall bladder strips.
  • M. Amer
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1972
The hypothesis is advanced that CCK acted in this preparation either by mechanisms independent of cyclic AMP or by stimulating phosphodiesterase and lowering a small pool of cyclIC AMP since the total cyclicAMP levels were not significantly reduced.
Studies with cholecystokinin in vitro. IV. Effects of cholecystokinin and related peptides on phosphodiesterase.
The hypothesis is presented that gastrin and cholecystokinin may act via stimulation of PDE and a resultant decrease in intracellular cyclic 3', 5'-adenosine monophosphate levels which provides an explanation for the antagonism between each of these hormones and secretin on gastric acid secretion.