Quercetin relaxes guinea pig gallbladder strips.

@article{Kline2016QuercetinRG,
  title={Quercetin relaxes guinea pig gallbladder strips.},
  author={Loren W. Kline and Edward Karpinski},
  journal={Nutrition research},
  year={2016},
  volume={36 10},
  pages={
          1098-1104
        }
}
The Flavone Luteolin, an Endocrine Disruptor, Relaxed Male Guinea Pig Gallbladder Strips
  • L. Kline
  • Biology, Medicine
    Gastroenterology research
  • 2019
TLDR
In this study, luteolin relaxed cholecystokinin- or KCl-induced tension by blocking extracellular Ca2+ entry as well as intracellular Ca 2+ release and the actions of PKA are also involved in mediating the lutenolin effect.
Relaxant Activities of Extracts from Uvaria rufa Blume and Caesalpinia sappan L. on Excised Rat’s Prostate Strips
TLDR
The ethyl acetate from the stems of U. rufa was the most potent in relaxing the prostate smooth muscles, and it may be useful to relieve the urological symptoms caused by benign prostatic hyperplasia (BPH).
2-aminoethyldiphenyl borinate: a multitarget compound with potential as a drug precursor.
TLDR
The molecular pharmacology of 2-APB supports both its potential to act as a drug and the desirable inclusion of its moieties in new drug development.

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The mechanical and electrophysiological properties of quercetin and its rutoside, rutin, are investigated in an attempt to clarify how Ca2+ channel activation might be related to the myorelaxing activity.
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Calcitonin gene-related peptide (CGRP) relaxes vascular and intestinal smooth muscle and may in part act directly on the gallbladder smooth muscle to inhibit contraction.
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Naringenin and quercetin inhibit peristalsis by facilitating inhibitory enteric pathways, whereas apigenin and genistein interfere with muscle excitation or excitation-contraction coupling.
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  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
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TLDR
The hypothesis is advanced that CCK acted in this preparation either by mechanisms independent of cyclic AMP or by stimulating phosphodiesterase and lowering a small pool of cyclIC AMP since the total cyclicAMP levels were not significantly reduced.
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TLDR
The hypothesis is presented that gastrin and cholecystokinin may act via stimulation of PDE and a resultant decrease in intracellular cyclic 3', 5'-adenosine monophosphate levels which provides an explanation for the antagonism between each of these hormones and secretin on gastric acid secretion.
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