Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production.

@article{Valrio2009QuercetinRI,
  title={Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production.},
  author={Daniel Augusto Rodrigues Val{\'e}rio and Sandra Regina Georgetti and Danilo A. Magro and R{\'u}bia Casagrande and Thiago M Cunha and Fabiana Testa Moura de Carvalho Vicentini and Silvio M Vieira and Maria Jos{\'e} Vieira Fonseca and S{\'e}rgio Henrique Ferreira and Fernando Q Cunha and Waldiceu A Verri},
  journal={Journal of natural products},
  year={2009},
  volume={72 11},
  pages={1975-9}
}
Quercetin (1) is known to have both antioxidant and antinociceptive effects. However, the mechanism involved in its antinociceptive effect is not fully elucidated. Cytokines and reactive oxygen species have been implicated in the cascade of events resulting in inflammatory pain. Therefore, we evaluated the antinociceptive mechanism of 1 focusing on the role of cytokines and oxidative stress. Intraperitoneal and oral treatments with 1 dose-dependently inhibited inflammatory nociception induced… CONTINUE READING