Quercetin promotes the osteogenic differentiation of rat mesenchymal stem cells via mitogen-activated protein kinase signaling.

@article{Li2015QuercetinPT,
  title={Quercetin promotes the osteogenic differentiation of rat mesenchymal stem cells via mitogen-activated protein kinase signaling.},
  author={Yang Li and Jiefang Wang and Guangming Chen and Shuiwang Feng and Panpan Wang and Xiao-feng Zhu and Ronghua Zhang},
  journal={Experimental and therapeutic medicine},
  year={2015},
  volume={9 6},
  pages={2072-2080}
}
The aim of the present study was to investigate the effects of quercetin on the mitogen-activated protein kinase (MAPK) signaling pathway in the osteogenic differentiation of rat mesenchymal stem cells (MSCs). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and an alkaline phosphatase (ALP) assay were used to determine the effects of quercetin (concentrations of 0.1, 1 and 10 µmol/l) on the proliferation and differentiation of MSCs and the expression of ALP, respectively… CONTINUE READING