Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells.

@article{Jackson2006QuercetinIE,
  title={Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells.},
  author={Steven J T Jackson and Richard C. Venema},
  journal={The Journal of nutrition},
  year={2006},
  volume={136 5},
  pages={
          1178-84
        }
}
Quercetin (QRN), one of the most abundant flavonoids in the human diet, is a known antioxidant and inhibitor of cancer cell cycle progression. Here, we provide the first evidence that QRN inhibits angiogenesis via a mechanism involving both suppression of endothelial nitric oxide synthase (eNOS) and early M-phase cell cycle arrest. Bovine aortic endothelial (BAE) cells were exposed to doses of up to 100 micromol/L QRN and assayed for eNOS activity and phosphorylation status. Phosphorylation of… 
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