Quercetin induces structural chromosomal aberrations and uncommon rearrangements in bovine cells transformed by the E7 protein of bovine papillomavirus type 4.

@article{Leal2003QuercetinIS,
  title={Quercetin induces structural chromosomal aberrations and uncommon rearrangements in bovine cells transformed by the E7 protein of bovine papillomavirus type 4.},
  author={A. M. Leal and O. Ferraz and C. Carvalho and A. C. Freitas and R. Beniston and W. Beçak and M. Campo and R. C. Stocco dos Santos},
  journal={Veterinary and comparative oncology},
  year={2003},
  volume={1 1},
  pages={
          15-21
        }
}
Bovine papillomavirus type 4 (BPV-4) and bracken fern are cofactors in the carcinogenesis of the upper gastrointestinal (GI) tract of cattle. An experimental in vitro model system has been developed to analyse the co-operation between the viral transforming protein E7, the cellular ras oncogene and quercetin, one of the mutagens of bracken fern, during neoplastic progression of primary bovine cells. We now report cytogenetic studies of these cells at different stages of malignant transformation… Expand
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