Quercetin induces hepatic γ-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p.

@article{Wein2015QuercetinIH,
  title={Quercetin induces hepatic $\gamma$-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p.},
  author={Silvia Wein and Alessandro Laviano and Siegfried Wolffram},
  journal={The Journal of nutritional biochemistry},
  year={2015},
  volume={26 12},
  pages={
          1660-3
        }
}
Exogenous factors such as food components including the flavonoid quercetin are suspected to influence micro RNA (miRNA) concentrations and thus possibly target enzymes involved in xenobiotic metabolism. This study therefore investigates the influence of orally administered quercetin on hepatic miRNA and the identification of enzyme target mRNAs relevant in drug metabolism. Male Wistar rats (n=16) were fed either a diet without (C) or with (Q) the addition of 100-ppm quercetin for 7 weeks and… Expand
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References

SHOWING 1-10 OF 50 REFERENCES
Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice.
TLDR
The data indicate that plant-derived polyphenols should be tested in humans as preventive rather than therapeutic agents in the regulation of hepatic fatty acid utilization. Expand
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.
TLDR
IMR-122 inhibition in a diet-induced obesity mouse model resulted in decreased plasma cholesterol levels and a significant improvement in liver steatosis, accompanied by reductions in several lipogenic genes, suggesting that miR- 122 may be an attractive therapeutic target for metabolic disease. Expand
Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis.
TLDR
The aim of this review is to present up-to-date data on the control of microRNA expression by dietary phytophenols in different types of human cells, and their impact on cell differentiation, cancer development and the regulation of the inflammatory response. Expand
Oral Bioavailability of Quercetin in Horses
Quercetin, one of the most abundant flavonoids in plants, is discussed with respect to health-promoting effects like antioxidative and anti-inflammatory properties. Although most claims regardingExpand
The flavonoid quercetin in disease prevention and therapy: facts and fancies.
TLDR
Quercetin can be considered the prototype of a naturally-occurring chemopreventive agent because of its key roles in triggering the "hallmarks of cancer" and several critical points must be taken into account when considering the potential therapeutic use of this molecule. Expand
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.
TLDR
The cancer protective effects of flavonoids have been attributed to a wide variety of mechanisms, including modulating enzyme activities resulting in the decreased carcinogenicity of xenobiotics and phase II enzymes, largely responsible for the detoxification of carcinogens. Expand
Effects of Viscum album L. extract and quercetin on methotrexate-induced cyto-genotoxicity in mouse bone-marrow cells.
TLDR
It is suggested that VAE and QE may play a role in reducing cyto-genotoxicity induced by anti-neoplastic drugs during cancer chemotherapy. Expand
Chronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration
TLDR
Effects seen after acute concomitant intake are rather explained by induced salicylamide excretion from the intestinal mucosa, whereas quercetin pre-treatment seemed to induce hepatic enzymes involved in phase-II metabolism and thereby enhanced elimination of SAM. Expand
Effects of the flavonol quercetin on the bioavailability of simvastatin in pigs.
TLDR
It is concluded that chronic ingestion of high doses of the flavonol quercetin will decrease the bioavailability of simvastatin to a significant extent. Expand
High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer
TLDR
It is suggested that GGH serve as a potential biomarker of unfavorable clinical outcomes over short-term follow-up in breast cancer, and cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer. Expand
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