Quercetin induces hepatic γ-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p.

  title={Quercetin induces hepatic $\gamma$-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p.},
  author={Silvia Wein and Alessandro Laviano and Siegfried Wolffram},
  journal={The Journal of nutritional biochemistry},
  volume={26 12},
Exogenous factors such as food components including the flavonoid quercetin are suspected to influence micro RNA (miRNA) concentrations and thus possibly target enzymes involved in xenobiotic metabolism. This study therefore investigates the influence of orally administered quercetin on hepatic miRNA and the identification of enzyme target mRNAs relevant in drug metabolism. Male Wistar rats (n=16) were fed either a diet without (C) or with (Q) the addition of 100-ppm quercetin for 7 weeks and… Expand
Effects of quercetin on microRNAs: A mechanistic review
This review aimed to summarize the studies focused on the effects of quercetin on different miRNA expressions to more clear the main possible mechanisms of quERCetin influences and introduce it as a beneficial agent for regulation of miRNAs in various biological directions. Expand
Quercetin ameliorates lipopolysaccharide-caused inflammatory damage via down-regulation of miR-221 in WI-38 cells.
It is revealed that quercetin ameliorated LPS-caused inflammatory damage of WI-38 lung fibroblasts might be through down-regulation of miR-221 and inactivation of NF-κB and JNK pathways. Expand
MicroRNAs as molecular targets of quercetin and its derivatives underlying their biological effects: A preclinical strategy
This article reviews the studies into the molecular pathways underlying the beneficial bioactivities of quercetin and its derivatives, and the modulatory effects of miRNAs by quercETin andIts derivatives on miRN as well as the roles of mi RNAs in overall nutritional control. Expand
The effect of quercetin on microRNA expression: A critical review.
  • Z. Dostál, M. Modriansky
  • Medicine
  • Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
  • 2019
This review is an evaluation of the recent relevant literature on the ability of quercetin to modulate miRNA expression and includes a summary of recent knowledge on miRNAs deregulated by quercettin, an overview of quERCetin pharmacokinetics and miRNA biogenesis, for the interested reader. Expand
Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells
Flavonoid compounds from citrus peel suppressed miR-122 andMiR-33 expression, which were induced by oleic acid, and these changes are most likely the principal mechanisms leading to decreased lipid accumulation in HepG2 cells. Expand
MicroRNA targeting by quercetin in cancer treatment and chemoprotection.
The data supporting the use of quercetin for miRNA-mediated chemopreventive and therapeutic strategies in various cancers is reviewed with the aim of comprehensively understand its health-promoting benefits and pharmacological potential. Expand
A Low Dose of Dietary Quercetin Fails to Protect against the Development of an Obese Phenotype in Mice
Quercetin administration had no effect at mitigating increases in visceral AT, AT inflammation, hepatic steatosis, ER Stress, decrements in hepatic oxidative capacity, or the development of insulin resistance and hypercholesterolemia. Expand
Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention
  • B. Biersack
  • Biology, Medicine
  • Non-coding RNA research
  • 2016
The effects of naturally occurring small molecules (phenolic compounds and terpenoids) on miRNAs involved in cancer diseases are reviewed. Expand
MiR-125b-5p suppresses the bladder cancer progression via targeting HK2 and suppressing PI3K/AKT pathway
Overall, data indicate that miR-125b-5p played a role in the suppressive effect on BCa by targeting HK2 through suppressing PI3K/AKT pathway and offer a potential therapeutic target for BCa. Expand
miR-125b-5p inhibits breast cancer cell proliferation, migration and invasion by targeting KIAA1522.
Functional assays showed that miR-125b-5p functions as a tumor suppressor and regulates BC progression through targeting KIAA1522 and shows that cell proliferation, colony formation ability, cell migration, and cell invasion can be suppressed by miR+5p overexpression. Expand


Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice.
The data indicate that plant-derived polyphenols should be tested in humans as preventive rather than therapeutic agents in the regulation of hepatic fatty acid utilization. Expand
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.
IMR-122 inhibition in a diet-induced obesity mouse model resulted in decreased plasma cholesterol levels and a significant improvement in liver steatosis, accompanied by reductions in several lipogenic genes, suggesting that miR- 122 may be an attractive therapeutic target for metabolic disease. Expand
Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis.
The aim of this review is to present up-to-date data on the control of microRNA expression by dietary phytophenols in different types of human cells, and their impact on cell differentiation, cancer development and the regulation of the inflammatory response. Expand
Oral Bioavailability of Quercetin in Horses
Quercetin, one of the most abundant flavonoids in plants, is discussed with respect to health-promoting effects like antioxidative and anti-inflammatory properties. Although most claims regardingExpand
The flavonoid quercetin in disease prevention and therapy: facts and fancies.
Quercetin can be considered the prototype of a naturally-occurring chemopreventive agent because of its key roles in triggering the "hallmarks of cancer" and several critical points must be taken into account when considering the potential therapeutic use of this molecule. Expand
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.
The cancer protective effects of flavonoids have been attributed to a wide variety of mechanisms, including modulating enzyme activities resulting in the decreased carcinogenicity of xenobiotics and phase II enzymes, largely responsible for the detoxification of carcinogens. Expand
Effects of Viscum album L. extract and quercetin on methotrexate-induced cyto-genotoxicity in mouse bone-marrow cells.
It is suggested that VAE and QE may play a role in reducing cyto-genotoxicity induced by anti-neoplastic drugs during cancer chemotherapy. Expand
Chronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration
Effects seen after acute concomitant intake are rather explained by induced salicylamide excretion from the intestinal mucosa, whereas quercetin pre-treatment seemed to induce hepatic enzymes involved in phase-II metabolism and thereby enhanced elimination of SAM. Expand
Effects of the flavonol quercetin on the bioavailability of simvastatin in pigs.
It is concluded that chronic ingestion of high doses of the flavonol quercetin will decrease the bioavailability of simvastatin to a significant extent. Expand
High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer
It is suggested that GGH serve as a potential biomarker of unfavorable clinical outcomes over short-term follow-up in breast cancer, and cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer. Expand