Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.

@article{Granato2017QuercetinIA,
  title={Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.},
  author={Marisa Granato and Celeste Rizzello and Maria Saveria Gilardini Montani and Laura Cuomo and Marina Vitillo and Rapha{\"e}lle L. Santarelli and Roberta Gonnella and Gabriella D'Orazi and Alberto Faggioni and Mara Cirone},
  journal={The Journal of nutritional biochemistry},
  year={2017},
  volume={41},
  pages={
          124-136
        }
}
Quercetin, a bioflavonoid contained in several vegetables daily consumed, has been studied for long time for its antiinflammatory and anticancer properties. Quercetin interacts with multiple cancer-related pathways such as PI3K/AKT, Wnt/β-catenin and STAT3. These pathways are hyperactivated in primary effusion lymphoma (PEL), an aggressive B cell lymphoma whose pathogenesis is strictly linked to the oncogenic virus Kaposis' Sarcoma-associated Herpesvirus (KSHV). In this study, we found that… CONTINUE READING

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