Quercetin-induced induction of the NO/cGMP pathway depends on Ca2+-activated K+ channel-induced hyperpolarization-mediated Ca2+-entry into cultured human endothelial cells.

  title={Quercetin-induced induction of the NO/cGMP pathway depends on Ca2+-activated K+ channel-induced hyperpolarization-mediated Ca2+-entry into cultured human endothelial cells.},
  author={Christoph Ruediger Wolfram Kuhlmann and Christian Alexander Schaefer and Christoph Kosok and Yaser Abdallah and Sabine Walther and D{\"o}rte W L{\"u}dders and Thomas Neumann and Harald H Tillmanns and Claudia Sch{\"a}fer and Hans Michael Piper and Ali Riza Erdoğan},
  journal={Planta medica},
  volume={71 6},
Quercetin is one of the dietary-derived flavonoids that are held responsible for the beneficial effects of red wine drinking in coronary artery disease known as the "French paradox". We examined whether quercetin modulates endothelial function by influencing Ca2+-activated K+ channels with large conductance (BK(Ca)) in cultured human endothelial cells. Membrane potential and intracellular Ca2+ concentrations of cultured human endothelial cells derived from umbilical cord veins (HUVEC) were… 
Effect of procyanidin C1 on nitric oxide production and hyperpolarization through Ca(2+)-dependent pathway in endothelial cells.
  • M. Byun
  • Biology
    Journal of medicinal food
  • 2012
It is demonstrated for the first time that procyanidin C1 plays a potent role in promoting Ca(2+)-mediated signals such as the hyperpolarization via multiple K(+) channel activations and the NO release in RAECs, suggesting that proCyanid in C1 may represent novel and effective therapy for the treatment of cardiovascular diseases.
Quercetin-induced Growth Inhibition in Human Bladder Cancer Cells Is Associated with an Increase in Ca-activated K Channels.
  • Yangmi KimWun-Jae KimEun-Jong Cha
  • Biology
    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2011
Results indicate that activation of BK(Ca) channels may be considered an important target related to the action of quercetin on human bladder cancer cells.
Apigenin‐induced nitric oxide production involves calcium‐activated potassium channels and is responsible for antiangiogenic effects
The following signaling cascade is proposed for the effects of Api on endothelial cell signaling: Api activates small and large conductance KCa, leading to a hyperpolarization that is followed by a Ca2+ influx, responsible for an increased NO production that mediates the antiangiogenic effects ofApi via Akt dephosphorylation.
Quercetin depletes intracellular Ca2+ stores and blunts ATP‐triggered Ca2+ signaling in bEnd.3 endothelial cells
For the first time, quercetin perturbed intracellular Ca2+ stores and strongly suppressed ATP‐triggered response in bEnd.3 EC, and raised cytosolic Ca2-level in a concentration‐dependent manner.
The Effect of Quercetin on the BK Ca in Umbilical Cord Vein-derived Mesenchymal Stem Cells
Recently, we demonstrated that a large conductance Ca²?-activated K? channel (BK Ca ) in human umbilical cord vein-derived mesenchymal cells (hUC-MSCs). In this study, we studied effects of