Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages

@inproceedings{Chang2012QuercetinEA,
  title={Quercetin enhances ABCA1 expression and cholesterol efflux through a
p38-dependent pathway in macrophages},
  author={Yu-Cheng Chang and Tzong-Shyuan Lee and Alison Chiang},
  booktitle={Journal of lipid research},
  year={2012}
}
ATP-binding cassette transporter A1 (ABCA1) plays a crucial role in exporting cholesterol from macrophages, a function relevant to its involvement in the prevention of atherosclerosis. Quercetin, one of flavonoids, has been described to reduce atherosclerotic lesion formation. This study is aimed to investigate the effect of quercetin on regulation of ABCA1 expression and to explore its underlying mechanisms in macrophages. The results show that quercetin markedly enhanced cholesterol efflux… CONTINUE READING

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