Quercetin down-regulates signal transduction in human breast carcinoma cells.

  title={Quercetin down-regulates signal transduction in human breast carcinoma cells.},
  author={Radhey L. Singhal and Y A Yeh and N Praja and Edith Ol{\'a}h and George W. Sledge and George Weber},
  journal={Biochemical and biophysical research communications},
  volume={208 1},
Signal transduction activity was markedly elevated in cancer cells as shown by the increased activity of enzymes utilizing 1-phosphatidylinositol, PI (PI 4-kinase and PI-4-phosphate 5-kinase) for the production of the second messenger inositol 1,4,5-trisphosphate, IP3, in rat hepatomas (Cancer Res. 54: 2611;5574, 1994) and in human ovarian and breast carcinoma cells (Life Sci. 55:1487, 1994). Quercetin, a flavonoid, in human breast carcinoma MDA-MB-435 cells produced growth inhibition (IC50… CONTINUE READING


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