Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols.

@article{Marchi2009QuercetinCA,
  title={Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols.},
  author={Umberto De Marchi and Lucia Biasutto and Spiridione Garbisa and Antonio Toninello and Mario Zoratti},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1787 12},
  pages={1425-32}
}
The Ca(2+)- and oxidative stress-induced mitochondrial permeability transition (MPT) plays an important role in phenomena ranging from tissue damage upon infarction to muscle wasting in some forms of dystrophy. The process is due to the activation of a large pore in the inner mitochondrial membrane. Anti-oxidants are considered a preventive and remedial tool, and mitochondria-targeted redox-active compounds have been developed. Plant polyphenols are generally considered as anti-oxidants, and… CONTINUE READING

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