Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats.

@article{Qiu2018QuercetinAM,
  title={Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats.},
  author={Linan Qiu and Yuju Luo and Xiaojuan Chen},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2018},
  volume={103},
  pages={
          1585-1591
        }
}
Despite the severity of osteoarthritis (OA), current medical therapy strategies for OA aim at symptom control and pain reduction, as there is no ideal drug for effective OA treatment. OA rat model was used to explore the therapeutic function of quercetin on remission of OA, by determining the reactive oxygen species (ROS) levels, mitochondrial function and extracellular matrix integrity. Quercetin could attenuate ROS generation and augment the glutathione (GSH) and glutathione peroxidase (GPx… CONTINUE READING