Quercetin antagonism of GABAAρ₁ receptors is prevented by ascorbic acid through a redox-independent mechanism.

@article{Calero2013QuercetinAO,
  title={Quercetin antagonism of GABAAρ₁ receptors is prevented by ascorbic acid through a redox-independent mechanism.},
  author={Cecilia I. Calero and Andrea N Beltr{\'a}n Gonz{\'a}lez and Javier Gasulla and Silvia {\'A}lvarez and Pablo Evelson and Daniel J Calvo},
  journal={European journal of pharmacology},
  year={2013},
  volume={714 1-3},
  pages={274-80}
}
Quercetin is a natural flavonoid widely distributed in plants that acts as a neuroprotective agent and modulates the activity of different synaptic receptors and ion channels, including the ionotropic GABA receptors. GABA(Aρ₁) receptors were shown to be antagonized by quercetin, but the mechanisms underlying these antagonistic actions are still unknown. We have analyzed here if the antagonistic action produced by quercetin on GABA(Aρ₁) receptors was related to its redox activity or due to… CONTINUE READING