Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery.

@article{AlShalmani2011QuercetinAI,
  title={Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery.},
  author={Salmin Al-Shalmani and Sunita Suri and David Aled Hughes and Paul A Kroon and Paul W. Needs and Moira A Taylor and Sandra Tribolo and Vincent G. Wilson},
  journal={British journal of pharmacology},
  year={2011},
  volume={162 7},
  pages={
          1485-97
        }
}
BACKGROUND AND PURPOSE Quercetin is anti-inflammatory in macrophages by inhibiting lipopolysaccharide (LPS)-mediated increases in cytokine and nitric oxide production but there is little information regarding the corresponding effect on the vasculature. We have examined the effect of quercetin, and its principal human metabolites, on inflammatory changes in the porcine isolated coronary artery. EXPERIMENTAL APPROACH Porcine coronary artery segments were incubated overnight at 37°C in modified… CONTINUE READING
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