Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells

@inproceedings{DemirogluZergeroglu2016QuercetinAC,
  title={Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells},
  author={Asuman Demiroglu-Zergeroglu and Emel Ergene and Nurettin Ayvali and Victor Kuete and Hulya Sivas},
  booktitle={BMC complementary and alternative medicine},
  year={2016}
}
BACKGROUND Malignant mesothelioma is a locally aggressive and highly lethal neoplasm of pleural, peritoneal and pericardial mesothelial cells without successful therapy. Previously, we reported that Quercetin in combination with Cisplatin inhibits cell proliferation and activates caspase-9 and -3 enzymes in different malignant mesothelioma cell lines. Moreover, Quercetin + Cisplatin lead to accumulation of both SPC111 and SPC212 cell lines in S phase. METHODS In present work, 84 genes… CONTINUE READING