Quercetin and Ascorbic Acid Suppress Fructose-Induced NLRP3 Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell Lines

@article{Choe2017QuercetinAA,
  title={Quercetin and Ascorbic Acid Suppress Fructose-Induced NLRP3 Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell Lines},
  author={Jung-Yoon Choe and Seong Kyu Kim},
  journal={Inflammation},
  year={2017},
  volume={40},
  pages={980-994}
}
The aim of this study was to identify the role of thioredoxin-interacting protein (TXNIP) and its interaction with antioxidants in the activation of the fructose-induced NOD-like receptor protein 3 (NLRP3) inflammasome in human macrophages. The study was performed with U937 and THP-1 macrophage cell lines. Total reactive oxygen species (ROS) were measured by flow cytometry. Interleukin-1β (IL-1β), IL-18, NLRP3, TXNIP, and caspase-1 protein expression was detected using western blotting… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Reactive oxygen species - induced TXNIP drives fructose - mediated hepatic inflammation and lipid accumulation through NLRP 3 inflammasome activation

  • D. M. Zhang, C. H. Ma, +4 authors L. D. Kong
  • Antioxi - dants and Redox Signaling
  • 2016

Similar Papers

Loading similar papers…