Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-κB pathway.

  title={Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-$\kappa$B pathway.},
  author={M. Zhang and J. Lin and X. Li and J. Li},
  journal={Genetics and molecular research : GMR},
  volume={15 2}
  • M. Zhang, J. Lin, +1 author J. Li
  • Published 2016
  • Chemistry, Medicine
  • Genetics and molecular research : GMR
Quercetin, a dietary flavonoid abundant in fruits, vegetables, and herbs, presents various pharmacological effects. This study aimed to investigate the anti-inflammatory effect and the underlying mechanism of quercetin in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs). Cell viability was measured by the Cell Counting Kit-8 assay. The mRNA expression of Toll-like receptor 2 (TLR2) was assessed by quantitative real-time polymerase chain reaction. Inflammatory… Expand
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