Quercetin alleviated H2O2‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells

  title={Quercetin alleviated H2O2‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells},
  author={Manman Li and Yang Xue and Hao Yu and Da-gan Mao},
  journal={Journal of Biochemical and Molecular Toxicology},
  • Manman Li, Y. Xue, D. Mao
  • Published 15 May 2020
  • Biology
  • Journal of Biochemical and Molecular Toxicology
Quercetin (Que) is a natural flavonoid in most plants. Luteinized granulosa cell (LGC) culture is necessary for the study of follicle growth/differentiation. In the present study, we analyzed the role of Que in steroid production and apoptosis in hydrogen peroxide (H2O2)‐treated goat LGCs. The results showed that treatment with H2O2 induced apoptosis in goat LGCs, and treatment with Que decreased LGC apoptosis induced by H2O2 (P < .05), accompanied with the different expressions of BAX, BCL‐2… 
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