Quercetin alleviated H2O2‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells

@article{Li2020QuercetinAH,
  title={Quercetin alleviated H2O2‐induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells},
  author={Manman Li and Yang Xue and Hao Yu and Da-gan Mao},
  journal={Journal of Biochemical and Molecular Toxicology},
  year={2020},
  volume={34}
}
  • Manman Li, Y. Xue, D. Mao
  • Published 15 May 2020
  • Biology
  • Journal of Biochemical and Molecular Toxicology
Quercetin (Que) is a natural flavonoid in most plants. Luteinized granulosa cell (LGC) culture is necessary for the study of follicle growth/differentiation. In the present study, we analyzed the role of Que in steroid production and apoptosis in hydrogen peroxide (H2O2)‐treated goat LGCs. The results showed that treatment with H2O2 induced apoptosis in goat LGCs, and treatment with Que decreased LGC apoptosis induced by H2O2 (P < .05), accompanied with the different expressions of BAX, BCL‐2… 
2 Citations
MAGOH/MAGOHB Inhibits the Tumorigenesis of Gastric Cancer via Inactivation of b-RAF/MEK/ERK Signaling
TLDR
MAGOH knockdown inhibited the tumorigenesis of gastric cancer via mediation of b-RAF/MEK/ERK signaling, and double knockdown of MAGOH and MAGOHB exhibited much better anti-tumor effects.

References

SHOWING 1-10 OF 58 REFERENCES
Effects of NRF1 on steroidogenesis and apoptosis in goat luteinized granulosa cells.
TLDR
Results showed that knockdown of NRF1 expression significantly inhibited the expression of STAR and CYP19A1, which are involved in sex steroid hormones synthesis, and led to lower estrogen levels, indicating thatNRF1 might be related with steroidogenesis and cell apoptosis.
Dietary bioflavonoid quercetin modulates porcine ovarian granulosa cell functions in vitro
TLDR
Results confirm the safety of quercetin in porcine ovarian granulosa cell model and suggest its possible concentration-dependent influence on ovarian functions through pathway that may involve progesterone, cyclin B1 and p53.
The Phytoestrogen Quercetin Impairs Steroidogenesis and Angiogenesis in Swine Granulosa Cells In Vitro
TLDR
Data evidence shows that quercetin does not affect granulosa cell growth while it inhibits progesterone production and modifies estradiol 17β production in a dose-related manner, and the flavonoid interferes with the angiogenic process by inhibiting VEGF production as well as by altering redox status.
Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12) Cells
TLDR
It is demonstrated that quercetin exhibited a protective effect against oxidative stress-induced apoptosis in PC-12 cells, suggesting that quERCetin may be developed as a novel therapeutic agent for neurodegenerative diseases induced by oxidative stress.
Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway
TLDR
It is suggested that SFN pretreatment effectively protects GCs against oxidative damage through the activation of the NRF2-ARE pathway, whereas addition of SFN during oxidative insult failed to rescue GCs.
Endogenous and Exogenous Modulation of Nrf2 Mediated Oxidative Stress Response in Bovine Granulosa Cells: Potential Implication for Ovarian Function
TLDR
Overexpression of those miRNAs resulted in downregulation of Nrf2 expression resulted in higher ROS accumulation, reduced mitochondrial activity and cellular proliferation, and quercetin at a low dose played a protective role in bovine granulosa cells against oxidative stress damage.
The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway.
  • C. L. Saw, Yue Guo, A. Kong
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2014
Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro
TLDR
In vivo results demonstrated that quercetin had no effects on ovarian morphology, hormone secretion, or the estrous cycle in menopausal rats, and in vitro results indicated that quERCetin increased the antioxidant capacity of the ovary by upregulating the expression of some oxidative stress-related genes both in vivo and in vivo.
...
...