Quercetin Remodels the Tumor Microenvironment To Improve the Permeation, Retention, and Antitumor Effects of Nanoparticles.

@article{Hu2017QuercetinRT,
  title={Quercetin Remodels the Tumor Microenvironment To Improve the Permeation, Retention, and Antitumor Effects of Nanoparticles.},
  author={Kaili Hu and Lei Miao and Tyler Goodwin and Jun Li and Qi Liu and Leaf Huang},
  journal={ACS nano},
  year={2017},
  volume={11 5},
  pages={
          4916-4925
        }
}
Our previous work demonstrated that Wnt16 expression in cisplatin-damaged tumor-associated fibroblasts is a key factor contributing to cisplatin resistance in malignancies. Natural antifibrotic compounds with low toxicities are promising candidates to downregulate Wnt16 expression, improving the antitumor effect of cisplatin nanoparticles. Upon screening several natural chemicals, we found that a dietary flavonoid, quercetin, significantly suppresses Wnt16 expression in activated fibroblasts… CONTINUE READING

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